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Institut Sophia Agrobiotech

Institut Sophia Agrobiotech

Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs
Inra PACA
400 route des chappes
BP 167
0690 Sophia Antipolis Cedex
FRANCE
Tel. : +33(0)4 92 38 64 00
Fax : + 33(0)4 92 38 64 01

http://www.paca.inra.fr/institut-sophia-agrobiotech

Effector triggered immunity in animals: learning on the fly

Vendredi 8 décembre 2017 - 11:00 - Sophia Antipolis - Inra PACA - Salle A010

Séminaire scientifique
Dans le cadre de l'animation scientifique de l'Institut Sophia Agrobiotech, l'équipe IPO invite Laurent Boyer, Bâtiment Universitaire ARCHIMED, INSERM U1065, C3M, Nice CEDEX 3 : "Effector triggered immunity in animals: learning on the fly"

Résumé

How does the innate immune system recognize virulent microbes? And how do these microbes escape this immune response? Knowing that the pathogenic bacteria specifically express virulence factors, we looked for mechanisms able to detect the activity of these factors. Using models of Escherichia coli infection in both Drosophila and mice, we determined the importance of effector triggered immunity (ETI) in animals. We also found that a second bacterial factor HlyA counteracting ETI and allowing the ITU89 strain to be fully virulent. At the molecular level, our latest results in mice indicate that activation of the immune system involves the activation of caspase-1 and the recruitment of an inflammasome involving the ASC adapter to allow for the maturation of IL-1beta. Our work aims to determine the innate immune signaling as well as the molecular mechanism used by the pathogenic bacteria to block this immune response. Our long-term goal is to propose new strategies to stimulate host defense and detect AVI-deficient patients, which may be relevant for many infectious diseases.

 

Selected references:

  • Keller HBoyer LAbad P. (2016) Disease susceptibility in the Zig-Zag model of host-microbe interactions: only a consequence of immune suppression? Mol Plant Pathol.  May;17(4):475-9. 
  • Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, Goncalves D, Luci C, Marchetti S, Demon D, Degos C, Bechah Y, Mege JL, Lamkanfi M, Auberger P, Gorvel JP, Stuart LM, Landraud L, Lemichez E and Boyer L. (2015) Escherichia coli α-Hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia. PLoS Pathogens. 17;11(3):e1004732.
  • Stuart LMPaquette NBoyer L. (2013) Effector-triggered versus pattern-triggered immunity: how animals sense pathogensNature Reviews Immunology. Mar;13(3):199-206. 
  • Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM.(2011) Pathogen-Derived Effectors Trigger Protective Immunity via Activation of the Rac2 Enzyme and the IMD or Rip Kinase Signaling Pathway Immunity. Oct 28;35(4):536-49