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Institut Sophia Agrobiotech

Institut Sophia Agrobiotech

Institut Sophia Agrobiotech

UMR INRA - Univ. Nice Sophia Antipolis - Cnrs
Inra PACA
400 route des chappes
BP 167
0690 Sophia Antipolis Cedex
FRANCE
Tel. : +33(0)4 92 38 64 00
Fax : + 33(0)4 92 38 64 01

http://www.paca.inra.fr/institut-sophia-agrobiotech

The enteroendocrine peptide DH31 triggers intestinal contractions favoring the elimination of opportunistic vegetative bacteria but not spores

Vendredi 14 Avril - 11:00 - Sophia Antipolis - Inra PACA - Salle A010

Séminaire scientifique
Dans le cadre de l'animation scientifique de l'Institut Sophia Agrobiotech, Armel Gallet, équipe BES, nous présentera ses travaux sur : "The enteroendocrine peptide DH31 triggers intestinal contractions favoring the elimination of opportunistic vegetative bacteria but not spores".

Abstract

The digestive tract is the first organ in contact with the bacteria ingested along with food. While commensal bacteria become resident, opportunistic or virulent bacteria are rapidly eliminated from the gut. Using the host-pathogen interaction between Drosophila melanogaster and Bacillus thuringiensis, we characterized a new mechanism of defense corresponding to a huge visceral contraction (we named pathological contraction) required to help to eliminate the ingested vegetative bacteria. We showed that this visceral contraction is induced by the presence of the immune ROS in the lumen and is relayed by the enteroendocrine cells that secrete the DH31 neuropeptide. Consequently in less than 1 hour post-ingestion, the visceral muscle strongly contracts favoring vegetative bacteria expelling. Finally, we showed that Bacillus thuringiensis spores (used as bioinscticide) persist for a longer time in the intestine because they are not detected by the local innate immune system of the anterior midgut.